Monoamine oxidase inhibitors in depression.
نویسندگان
چکیده
منابع مشابه
Monoamine Oxidase Inhibitors and Their Role in Depression
The role of the monoamines, serotonin in mental illnesses including depression is well recognized. All antidepressant drugs in clinical use increase acutely the availability of these monoamines at the synapse either by inhibiting their neuronal reuptake, inhibiting their intraneuronal metabolism, or increasing their release by blocking the α2 autoand heteroreceptors on the monoaminergic neuron....
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comparisons be possible. The real differences in surgical mortality that do exist between surgeons and centres may teach important lessons. One study compared mortality between a teaching hospital and its adjacent district hospital and led to a proper intensive care unit being provided in the district hospital. 14 The confidential inquiry into perioperative deaths emphasised the value of regula...
متن کامل[Monoamine oxidase inhibitors].
Monoamine Oxidase Inhibitors DEAR SIR, Dr Pare's article on †̃¿ The Present Status of Monoamine Oxidase Inhibitors' is one of a genre that marks the renaissance of these drugs (Murphy et al, 1984; White & Simpson, 1985). This is understandable given that the †̃¿ second generation' compounds are less exciting than hoped, that early use of phenelzine was often with inadequate dosage and that im...
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As with many psychiatric drugs, the discovery of irreversible MAOIs was serendipitous. While being used as an antitubercular agent in the 1950s, iproniazid—a derivative of the hydrazine compound isocarboxazid—was observed to have significant antidepressant properties. Almost at the same time as the discovery of TCAs such as amitriptyline and imipramine (which were also discovered by chance), MA...
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gations: chest x-ray normal; Hb 55%; W.B.C. 7,100 with normal diffierential; iron deficiency on the blood film; E.S.R. 138 mm. in one hour; Paul-Bunnell test negative. Blood culture revealed Haemophilus influenzae type B sensitive to all the usual antibiotics except sulphonamide. This child was treated with ampicillin and made a good recovery. My point in recording this case history is to empha...
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ژورنال
عنوان ژورنال: BMJ
سال: 1982
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.285.6355.1594